These have been concerns raised about the health equity impacts of GLP-1s in the U.S., discussed recently: In Circulation in July 2024 In Lancet in June 2024 In Pharmaceutical Executive in March 2024 In this essay on the Omada Health portal, and, In the Kaiser Family Foundation Health Tracking Poll conducted in May 2024
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This study provides the first demonstration that GLP-1 analogs can be effective in treating obesity associated with MC4R deficiency in mice, offering new therapeutic possibilities for patients lacking the POMC-MC4R pathway
For example, pyruvate kinase muscle isoform 2 (PKM2) inactivation can both attenuate the glucose flux to PPP and enhance folate metabolism to mediate NADPH generation
Ongoing follow up can help clinicians monitor side effects, treatment progress and long term weight management outcomes more safely